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1667-11-4

1667-11-4 structure
1667-11-4 structure

Name 4-Biphenylmethyl chloride
Synonyms 4-(Chloromethyl)-1,1'-biphenyl
4-(Chloromethyl)biphenyl
1-(chloromethyl)-4-phenylbenzene
1,1'-Biphenyl, 4-(chloromethyl)-
EINECS 216-786-5
Biphenyl, 4- (chloromethyl)-
MFCD00000917
Density 1.1±0.1 g/cm3
Boiling Point 322.4±21.0 °C at 760 mmHg
Melting Point 70-73 °C(lit.)
Molecular Formula C13H11Cl
Molecular Weight 202.679
Flash Point 143.2±14.7 °C
Exact Mass 202.054932
LogP 4.24
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.579
Material Safety Data Sheet

Section1. Identification of the substance
Product Name: 4-(Chloromethyl)biphenyl
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315:Causes skin irritation
H319:Causes serious eye irritation
H335:May cause respiratory irritation
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

Section3. Composition/information on ingredients.
Ingredient name:4-(Chloromethyl)biphenyl
CAS number:1667-11-4

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
Eye contact:
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
No data
Boiling point:
Melting point:No data
Flash point:No data
Density:No data
Molecular formula: C13H11Cl
Molecular weight: 202.7

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen chloride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DV2087000
CHEMICAL NAME :
Biphenyl, 4-(chloromethyl)-
CAS REGISTRY NUMBER :
1667-11-4
BEILSTEIN REFERENCE NO. :
1863327
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C13-H11-Cl
MOLECULAR WEIGHT :
202.69
WISWESSER LINE NOTATION :
G1R DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
250 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2500 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - hamster Kidney
DOSE/DURATION :
2500 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 2,33,1981
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DV2087000
HS Code 2903999090

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Literature: DasGupta, Shirshendu; Murumkar, Prashant R.; Giridhar, Rajani; Yadav, Mange Ram Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3604 - 3617

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Literature: Ortho Pharmaceutical Corporation Patent: US5696117 A1, 1997 ; US 5696117 A

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Literature: Wang, Zhentao; Zhu, Lin; Yin, Feng; Su, Zhongquan; Li, Zhaodong; Li, Chaozhong Journal of the American Chemical Society, 2012 , vol. 134, # 9 p. 4258 - 4263

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Literature: Journal of Organic Chemistry, , vol. 56, # 5 p. 1747 - 1758

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Literature: Janczewski, Marian; Pekalska, Janina Polish Journal of Chemistry, 1988 , vol. 62, # 4-6 p. 389 - 402

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Literature: Journal of the American Chemical Society, , vol. 103, # 17 p. 5176 - 5179

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Literature: Recueil des Travaux Chimiques des Pays-Bas, , vol. 69, p. 1109,1115

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Literature: DE509149 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 428

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Detail
Literature: Chemische Berichte, , vol. 66, p. 1471,1474
HS Code 2903999090
Summary 2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%