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485-63-2

485-63-2 structure
485-63-2 structure
  • Name: 3',4',7-trihydroxy isoflavone
  • Chemical Name: 3',4',7-trihydroxyisoflavone
  • CAS Number: 485-63-2
  • Molecular Formula: C15H10O5
  • Molecular Weight: 270.24
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-09-12 20:33:32
  • Modify Date: 2024-01-03 00:15:34
  • 7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].

Name 3',4',7-trihydroxyisoflavone
Synonyms 7,3',4'-THIF
3-(3,4-Dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one
3',4',7-Trihydroxyisoflavone
3`,4`,7-Trihydroxyisoflavone
4H-1-Benzopyran-4-one, 3-(3,4-dihydroxyphenyl)-7-hydroxy-
3l5r
MFCD00143002
3-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-on
3',4',7-trihydroxy isoflavone
3'-Hydroxydaidzein
3-(3,4-dihydroxyphenyl)-7-hydroxychromen-4-one
3-(3,4-dihydroxy-phenyl)-7-hydroxy-chromen-4-one
7,3',4'-Trihydroxyisoflavone
7-Hydroxy-3-(3,4-dihydroxyphenyl)-4H-chromen-4-one
4H-1-Benzopyran-4-one,3-(3,4-dihydroxyphenyl)-7-hydroxy
Description 7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].
Related Catalog
In Vitro 7,3',4'-Trihydroxyisoflavone triggers cell cycle arrest at the G1 phase and displays an anti-proliferative effect against EGF receptor-positive skin cancer[1]. 7,3',4'-Trihydroxyisoflavone also significantly inhibits UVB-induced COX-2 expression by suppressing the NF-B transcription activity in mouse skin epidermal JB6 P+ cells[1].
In Vivo In a mouse skin tumorigenesis model, 7,3',4'-Trihydroxyisoflavone strongly suppresses the incidence, multiplicity, and volume of UVB-induced mouse skin tumors. Consistent with the tumor data, 7,3',4'-Trihydroxyisoflavone clearly attenuates UVB-induced COX-2 expression in hairless mouse skin[2].
References

[1]. Yu-Li Lo, et al. 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology. 2012 Dec 16;302(2-3):221-32.

[2]. Dong Eun Lee, et al. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem. 2011 Apr 22;286(16):14246-56.

Density 1.5±0.1 g/cm3
Boiling Point 572.8±50.0 °C at 760 mmHg
Melting Point 280-282°C
Molecular Formula C15H10O5
Molecular Weight 270.24
Flash Point 224.0±23.6 °C
Exact Mass 270.052826
PSA 90.90000
LogP 2.58
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.732
Storage condition -20°C Freezer
Stability Store in Freezer
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
WGK Germany 3