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5875-06-9

5875-06-9 structure
5875-06-9 structure
  • Name: Proparacaine Hydrochloride
  • Chemical Name: Proxymetacaine Hydrochloride
  • CAS Number: 5875-06-9
  • Molecular Formula: C16H27ClN2O3
  • Molecular Weight: 330.850
  • Catalog: API Anesthetic Agents Local anesthetics
  • Create Date: 2018-05-30 08:00:00
  • Modify Date: 2024-01-02 09:12:20
  • Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.IC50 Value: 3.4 mM(ED50) [1]Target: Sodium Channelin vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade [4].
Name Proxymetacaine Hydrochloride
Synonyms EINECS 227-541-7
3-amino-4-propoxybenzoate de 2-(diéthylamino)éthyle chlorhydrate
2-(Diethylamino)ethyl-3-amino-4-propoxybenzolcarboxylathydrochlorid
Proxymetacaine Hydrochloride
Proxymetacaine Hcl
2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride (1:1)
Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
2-(diethylamino)ethyl 3-amino-4-propoxybenzoate,hydrochloride
PROPARACAINE HCL
Proparacaine hydrochloride
MFCD00083467
2-(diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride
ak-taine
Description Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.IC50 Value: 3.4 mM(ED50) [1]Target: Sodium Channelin vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade [4].
Related Catalog
References

[1]. Grant, R.L. and D. Acosta, Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Exp Eye Res, 1994. 58(4): p. 469-78.

[2]. Segarra, S., K. Papasouliotis, and C. Helps, The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Vet Ophthalmol, 2011. 14 Suppl 1:

[3]. Dass, B.A., H.K. Soong, and B. Lee, Effects of proparacaine on actin cytoskeleton of corneal epithelium. J Ocul Pharmacol, 1988. 4(3): p. 187-94.

[4]. Hung, C.H., et al., Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett, 2009. 454(3): p. 249-53.
Boiling Point 434.4ºC at 760mmHg
Molecular Formula C16H27ClN2O3
Molecular Weight 330.850
Flash Point 216.5ºC
Exact Mass 330.171021
PSA 64.79000
LogP 3.93940
Storage condition -20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG3065000
CHEMICAL NAME :
Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, hydrochloride
CAS REGISTRY NUMBER :
5875-06-9
LAST UPDATED :
199504
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C16-H26-N2-O3.Cl-H
MOLECULAR WEIGHT :
330.90
WISWESSER LINE NOTATION :
3OR BZ DVO2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3371 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,269,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3223 No. of Facilities: 412 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3442 (estimated) No. of Female Employees: 2127 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H317-H319-H332
Precautionary Statements P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R20/21/22;R36;R43
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DG3065000

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