Proparacaine Hydrochloride

Modify Date: 2024-01-02 09:12:20

Proparacaine Hydrochloride structure	Common Name	Proparacaine Hydrochloride
	CAS Number	5875-06-9	Molecular Weight	330.850
	Density	N/A	Boiling Point	434.4ºC at 760mmHg
	Molecular Formula	C₁₆H₂₇ClN₂O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	216.5ºC
	Symbol	GHS07	Signal Word	Warning

Use of Proparacaine Hydrochloride

Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.IC50 Value: 3.4 mM(ED50) [1]Target: Sodium Channelin vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade [4].

Name	Proxymetacaine Hydrochloride
Synonym	More Synonyms

Description	Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.IC50 Value: 3.4 mM(ED50) [1]Target: Sodium Channelin vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade [4].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease Natural Products >> Others
References	[1]. Grant, R.L. and D. Acosta, Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Exp Eye Res, 1994. 58(4): p. 469-78. [2]. Segarra, S., K. Papasouliotis, and C. Helps, The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Vet Ophthalmol, 2011. 14 Suppl 1: [3]. Dass, B.A., H.K. Soong, and B. Lee, Effects of proparacaine on actin cytoskeleton of corneal epithelium. J Ocul Pharmacol, 1988. 4(3): p. 187-94. [4]. Hung, C.H., et al., Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett, 2009. 454(3): p. 249-53.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

Natural Products >> Others

References

[1]. Grant, R.L. and D. Acosta, Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Exp Eye Res, 1994. 58(4): p. 469-78.

[2]. Segarra, S., K. Papasouliotis, and C. Helps, The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Vet Ophthalmol, 2011. 14 Suppl 1:

[3]. Dass, B.A., H.K. Soong, and B. Lee, Effects of proparacaine on actin cytoskeleton of corneal epithelium. J Ocul Pharmacol, 1988. 4(3): p. 187-94.

[4]. Hung, C.H., et al., Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett, 2009. 454(3): p. 249-53.

Boiling Point	434.4ºC at 760mmHg
Molecular Formula	C₁₆H₂₇ClN₂O₃
Molecular Weight	330.850
Flash Point	216.5ºC
Exact Mass	330.171021
PSA	64.79000
LogP	3.93940
Storage condition	-20°C

Proparacaine Hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG3065000

CHEMICAL NAME :: Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 5875-06-9

LAST UPDATED :: 199504

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H26-N2-O3.Cl-H

MOLECULAR WEIGHT :: 330.90

WISWESSER LINE NOTATION :: 3OR BZ DVO2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3371 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,269,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3223 No. of Facilities: 412 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3442 (estimated) No. of Female Employees: 2127 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H317-H319-H332
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R20/21/22;R36;R43
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DG3065000

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EINECS 227-541-7

3-amino-4-propoxybenzoate de 2-(diéthylamino)éthyle chlorhydrate

2-(Diethylamino)ethyl-3-amino-4-propoxybenzolcarboxylathydrochlorid

Proxymetacaine Hydrochloride

Proxymetacaine Hcl

2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride (1:1)

Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)

2-(diethylamino)ethyl 3-amino-4-propoxybenzoate,hydrochloride

PROPARACAINE HCL

Proparacaine hydrochloride

MFCD00083467

2-(diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride

ak-taine

DC Chemicals Limited
China
Product Name: Proparacaine hydrochloride
Price: $Inquiry/25mg $Inquiry/50mg $Inquiry/250mg
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Proparacaine hydrochloride
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Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 5875-06-9 Proparacaine hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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