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4171-13-5

4171-13-5 structure
4171-13-5 structure
  • Name: Valnoctamide
  • Chemical Name: 2-ethyl-3-methyl-pentanamide Axiquel Nirvanil
  • CAS Number: 4171-13-5
  • Molecular Formula: C8H17NO
  • Molecular Weight: 143.22700
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
  • Create Date: 2018-04-22 08:00:00
  • Modify Date: 2025-08-24 17:44:47
  • Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors[1].
Name 2-ethyl-3-methyl-pentanamide Axiquel Nirvanil
Synonyms 2-ethyl-3-methylpentanamide
Valnoctamide
Description Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors[1].
Related Catalog
Target

GABAA receptor[1]

References

[1]. Spampanato J, et al. Valnoctamide enhances phasic inhibition: a potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus. Epilepsia. 2014 Sep;55(9):e94-8.
Density 0.883g/cm3
Boiling Point 274.4ºC at 760mmHg
Melting Point 113.5-114ºC
Molecular Formula C8H17NO
Molecular Weight 143.22700
Flash Point 119.8ºC
Exact Mass 143.13100
PSA 43.09000
LogP 2.24430
Index of Refraction 1.438

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YV5950000
CHEMICAL NAME :
Valeramide, 2-ethyl-3-methyl-
CAS REGISTRY NUMBER :
4171-13-5
BEILSTEIN REFERENCE NO. :
1749434
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C8-H17-N-O
MOLECULAR WEIGHT :
143.26
WISWESSER LINE NOTATION :
ZVY2&Y2&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,429,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
580 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,429,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
999 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 62,404,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,429,1972 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
700 mg/kg
SEX/DURATION :
female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 159,6,1965
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
female 6-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 159,6,1965
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport
RTECS YV5950000
HS Code 2924199090
82024-15-5 structure

82024-15-5

~%

4171-13-5 structure

4171-13-5

Literature: Kaufmann, Dan; Bialer, Meir; Shimshoni, Jakob Avi; Devor, Marshall; Yagen, Boris Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7236 - 7248
125-40-6 structure

125-40-6

~%

4171-13-5 structure

4171-13-5

Literature: Freifelder,M. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 203 - 206
105-43-1 structure

105-43-1

~%

4171-13-5 structure

4171-13-5

Literature: Kaufmann, Dan; Yagen, Boris; Minert, Anne; Wlodarczyk, Bogdan; Finnell, Richard H.; Schurig, Volker; Devor, Marshall; Bialer, Meir Neuropharmacology, 2010 , vol. 58, # 8 p. 1228 - 1236
22414-77-3 structure

22414-77-3

~%

4171-13-5 structure

4171-13-5

Literature: Katznelson; Kondakowa Doklady Akademii Nauk SSSR, 1934 , p. II 24 Chem. Zentralbl., 1935 , vol. 106, # I p. 2521
4372-17-2 structure

4372-17-2

~%

4171-13-5 structure

4171-13-5

Literature: Katznelson; Kondakowa Doklady Akademii Nauk SSSR, 1934 , p. II 24 Chem. Zentralbl., 1935 , vol. 106, # I p. 2521
HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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