85547-56-4
85547-56-4 structure
- Name: Piperaquine phosphate
- Chemical Name: 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
- CAS Number: 85547-56-4
- Molecular Formula: C29H35Cl2N6O4P
- Molecular Weight: 633.506
- Catalog: API Antiparasitic drug Antimalarial
- Create Date: 2018-06-21 10:53:50
- Modify Date: 2025-08-25 12:54:55
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Piperaquine is a bisquinoline antimalarial agent, often as a partner antimalarial for artemisinin drug-based combination therapy (ACT)[1][2].
| Name | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate |
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| Synonyms |
4,4'-(Propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline) phosphate (1:1)
Piperaquine phosphate 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate (1:1) Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro-, phosphate (1:1) |
| Description | Piperaquine is a bisquinoline antimalarial agent, often as a partner antimalarial for artemisinin drug-based combination therapy (ACT)[1][2]. |
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| Related Catalog | |
| In Vivo | Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1]. Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1]. Animal Model: Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1] Dosage: 0, 10, 30, 90 mg/kg Administration: A single i.p. administration Result: The median survival time was 10 days at dose of 10 mg/kg. The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg. Animal Model: Male Swiss mice (6 weeks old)[1] Dosage: 90 mg/kg (Pharmacokinetic Analysis) Administration: A single i.p. administration Result: t1/2=17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg. |
| References |
[2]. Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87. |
| Boiling Point | 721.1ºC at 760mmHg |
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| Molecular Formula | C29H35Cl2N6O4P |
| Molecular Weight | 633.506 |
| Flash Point | 389.9ºC |
| Exact Mass | 632.183472 |
| PSA | 126.31000 |
| LogP | 4.50130 |
| Storage condition | -20℃ |
| HS Code | 2942000000 |
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| HS Code | 2942000000 |
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