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Product Name: piperaquine phosphate
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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Piperaquine phosphate
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4085-31-8

4085-31-8 structure

4085-31-8 structure

Name: piperaquine phosphate
Chemical Name: Piperaquine phosphate
CAS Number: 4085-31-8
Molecular Formula: C₂₉H₃₂Cl₂N₆
Molecular Weight: 535.511
Catalog: API Antiparasitic drug Antimalarial
Create Date: 2018-04-22 08:00:00
Modify Date: 2024-01-02 19:32:18
Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[1][2].

Name	Piperaquine phosphate
Synonyms	Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro- 4,4'-(propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline) Piperaquine tetraphosphate tetrahydrate 7-Chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline Piperaquine piperaquinoline PIRERAQUINE PHOSPHATE 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline)

Description	Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[1][2].
Related Catalog	Research Areas >> Infection
In Vivo	Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1]. Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].
References	[1]. Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11. [2]. Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87.

Density	1.3±0.1 g/cm3
Boiling Point	721.1±60.0 °C at 760 mmHg
Melting Point	198-200°C (lit.)
Molecular Formula	C₂₉H₃₂Cl₂N₆
Molecular Weight	535.511
Flash Point	389.9±32.9 °C
Exact Mass	534.206543
PSA	38.74000
LogP	5.15
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.664

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC3280000

CHEMICAL NAME :: Quinoline, 4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro-

CAS REGISTRY NUMBER :: 4085-31-8

BEILSTEIN REFERENCE NO. :: 0905079

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C29-H32-Cl2-N6

MOLECULAR WEIGHT :: 535.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1098 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,273,1986

Hazard Codes	Xi
HS Code	2942000000

Precursor 3
109-64-8 837-52-5 86-98-6
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%