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934358-00-6

934358-00-6 structure
934358-00-6 structure
  • Name: TBCA
  • Chemical Name: 3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid
  • CAS Number: 934358-00-6
  • Molecular Formula: C9H4Br4O2
  • Molecular Weight: 463.743
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
  • Create Date: 2018-06-16 12:29:52
  • Modify Date: 2025-08-27 13:10:42
  • TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2].

Name 3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid
Synonyms (2E)-3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid
tetrabromocinnamic acid
2-Propenoic acid, 3-(2,3,4,5-tetrabromophenyl)-, (2E)-
(2E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
Description TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2].
Related Catalog
Target

CK2:110 nM (IC50)

CK2:77 nM (Ki)

In Vitro TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability[1]. TBCA also inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM[1]. TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including 2-MeSADP, AYPGKF, SFLLRN, and CRP. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF[2]. Cell Viability Assay[1] Cell Line: Jurkat cells Concentration: 0-100 μM Incubation Time: 24 hours Result: The viability of Jurkat cells was reduced.
References

[1]. Pagano MA, et al. Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem. 2007;8(1):129-139.

[2]. Ryu SY, Kim S. Evaluation of CK2 inhibitor (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid (TBCA) in regulation of platelet function. Eur J Pharmacol. 2013;720(1-3):391-400.

Density 2.4±0.1 g/cm3
Boiling Point 490.8±45.0 °C at 760 mmHg
Molecular Formula C9H4Br4O2
Molecular Weight 463.743
Flash Point 250.6±28.7 °C
Exact Mass 459.694458
PSA 37.30000
LogP 5.28
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.714
Hazard Statements H413
Hazard Codes Xi
RIDADR NONH for all modes of transport
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