36700-45-5

36700-45-5 structure

Name: 8-Shogaol
Chemical Name: (E)-1-(4-hydroxy-3-methoxyphenyl)dodec-4-en-3-one
CAS Number: 36700-45-5
Molecular Formula: C₁₉H₂₈O₃
Molecular Weight: 304.424
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-04-02 08:00:00
Modify Date: 2024-01-05 19:44:15
[8]-Shogaol, one of the pungent phenolic compounds in ginger, exhibits anti-platelet activity (IC50=5 μM) and inhibits COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis in human leukemia cells[1][2][3][4].

Name	(E)-1-(4-hydroxy-3-methoxyphenyl)dodec-4-en-3-one
Synonyms	4-Dodecen-3-one, 1-(4-hydroxy-3-methoxyphenyl)-, (4E)- (4E)-1-(4-hydroxy-3-methoxyphenyl)dodec-4-en-3-one 8-Shogaol (4E)-1-(4-Hydroxy-3-methoxyphenyl)-4-dodecen-3-one

Description	[8]-Shogaol, one of the pungent phenolic compounds in ginger, exhibits anti-platelet activity (IC50=5 μM) and inhibits COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis in human leukemia cells[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:17.5 μM (IC50)
References	[1]. Shieh PC, et al. Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. J Agric Food Chem. 2010 Mar 24;58(6):3847-54. [2]. van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43. [3]. Nurtjahja-Tjendraputra E, et al. Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res. 2003;111(4-5):259-65. [4]. Shieh PC, et al. Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. J Agric Food Chem. 2010 Mar 24;58(6):3847-54.