639052-78-1
639052-78-1 structure
- Name: LH846
- Chemical Name: N-(5-Chloro-6-methyl-2-benzothiazolyl)-benzeneacetamide
- CAS Number: 639052-78-1
- Molecular Formula: C16H13ClN2OS
- Molecular Weight: 316.805
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
- Create Date: 2017-09-18 16:18:29
- Modify Date: 2026-06-30 20:57:29
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LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.
| Name | N-(5-Chloro-6-methyl-2-benzothiazolyl)-benzeneacetamide |
|---|---|
| Synonyms |
N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Benzeneacetamide, N-(5-chloro-6-methyl-2-benzothiazolyl) inhibit,LH846,Inhibitor,Casein Kinase Casein Kinase I Inhibitor V, LH846 N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide LH LH846 >= (HPLC) LH 846, >= N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide LH 846; LH-846 LH-846 LH-846 N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide LH846, 10 mM in DMSO N-(5-CHLORO-6-METHYLBENZO[D]THIAZOL-2-YL)-2-PHENYLACETAMIDE LH 846, CK1delta inhibitor |
| Description | LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively. |
|---|---|
| Related Catalog | |
| Target |
CKIδ:290 nM (IC50) CKIϵ:1.3 μM (IC50) CKIα:2.5 μM (IC50) |
| In Vitro | LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C16H13ClN2OS |
| Molecular Weight | 316.805 |
| Exact Mass | 316.043701 |
| PSA | 73.72000 |
| LogP | 4.67 |
| Appearance | white solid |
| Index of Refraction | 1.709 |
| Storage condition | -20℃ |
