1164470-53-4

1164470-53-4 structure

Name: Sal003
Chemical Name: (2E)-3-Phenyl-N-(2,2,2-trichloro-1-{[(4-chlorophenyl)carbamothioy l]amino}ethyl)acrylamide
CAS Number: 1164470-53-4
Molecular Formula: C₁₈H₁₅Cl₄N₃OS
Molecular Weight: 463.208
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2017-03-08 08:01:56
Modify Date: 2024-01-01 21:42:41
Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal with enhanced aqueous solubility.IC50 value:Target: eIF2α phosphatase inhibitorSal003 has been shown to prevent dephosphorylation of eIF-2α which has been shown to regulate the late phase of long-term potentiation (LTP) and memory (LTM). This enhanced phosphorylated state of eIF-2α is shown to prevent L-LTP and suppress memory in mice.

Name	(2E)-3-Phenyl-N-(2,2,2-trichloro-1-{[(4-chlorophenyl)carbamothioy l]amino}ethyl)acrylamide
Synonyms	(2E)-3-Phenyl-N-(2,2,2-trichloro-1-{[(4-chlorophenyl)carbamothioyl]amino}ethyl)acrylamide (E)-1-(4-chlorophenyl)-3-(1,1,1-trichloro-4-oxo-6-phenylhex-5-en-2-yl)thiourea 2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-, (2E)- Sal003

Description	Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal with enhanced aqueous solubility.IC50 value:Target: eIF2α phosphatase inhibitorSal003 has been shown to prevent dephosphorylation of eIF-2α which has been shown to regulate the late phase of long-term potentiation (LTP) and memory (LTM). This enhanced phosphorylated state of eIF-2α is shown to prevent L-LTP and suppress memory in mice.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Cancer
References	[1]. Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45. [2]. Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. [3]. Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.