Name | Cyclic Pifithrin-α hydrobromide |
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Synonyms |
2-(p-Tolyl)-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazole Hydrobromide
2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole hydrobromide (1:1) 2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothia zole hydrobromide (1:1) Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1) Cyclic Pifithrin-α Hydrobromide Pifithrin-β (hydrobromide) |
Description | Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM. |
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Related Catalog | |
Target |
IC50: 23 μM (p53)[1] |
In Vitro | Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3]. |
References |
Molecular Formula | C16H17BrN2S |
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Molecular Weight | 349.289 |
Exact Mass | 348.029572 |
PSA | 45.54000 |
LogP | 5.20810 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |