Pifithrin-β (hydrobromide)

Modify Date: 2024-01-02 13:28:08

Pifithrin-β (hydrobromide) structure	Common Name	Pifithrin-β (hydrobromide)
	CAS Number	511296-88-1	Molecular Weight	349.289
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₇BrN₂S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Pifithrin-β (hydrobromide)

Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM.

Name	Cyclic Pifithrin-α hydrobromide
Synonym	More Synonyms

Description	Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM.
Related Catalog	Signaling Pathways >> Apoptosis >> MDM-2/p53 Research Areas >> Cancer
Target	IC50: 23 μM (p53)[1]
In Vitro	Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].
References	[1]. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57. [2]. Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation productpifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83. [3]. Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9.

Molecular Formula	C₁₆H₁₇BrN₂S
Molecular Weight	349.289
Exact Mass	348.029572
PSA	45.54000
LogP	5.20810

Pifithrin-β (hydrobromide) MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor.

Am. J. Respir. Cell. Mol. Biol. 44 , 323-32, (2011)

Exposure to cigarette smoke (CS) is the most common cause of emphysema, a debilitating pulmonary disease histopathologically characterized by the irreversible destruction of lung architecture. Mountin...

2-(p-Tolyl)-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazole Hydrobromide

2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole hydrobromide (1:1)

2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothia zole hydrobromide (1:1)

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Cyclic Pifithrin-α Hydrobromide

Pifithrin-β (hydrobromide)