154639-24-4

154639-24-4 structure

Name: (Rac)-RK-682
Chemical Name: rk-682
CAS Number: 154639-24-4
Molecular Formula: C₂₁H₃₆O₅
Molecular Weight: 368.51
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2017-12-11 01:19:41
Modify Date: 2024-01-06 20:01:16
(Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively[1].

Name	rk-682
Synonyms	ANTIBIOTIC RK-682 3-hexadecanoyl-5-hydroxymethyl-tetronic acid ANTIBIOTIC TAN 1364B

Description	(Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Target	IC50: 8.6 μM (PTP-1B), 12.4 μM (LMW-PTP), and 0.7 μM (CDC-25B) [1]
References	[1]. Vânia M T Carneiro, et al. Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. Eur J Med Chem. 2015 Jun 5;97:42-54.