(Rac)-RK-682

Modify Date: 2024-01-06 20:01:16

(Rac)-RK-682 Structure
(Rac)-RK-682 structure
Common Name (Rac)-RK-682
CAS Number 154639-24-4 Molecular Weight 368.51
Density N/A Boiling Point N/A
Molecular Formula C21H36O5 Melting Point N/A
MSDS Chinese Flash Point N/A

 Use of (Rac)-RK-682


(Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively[1].

 Names

Name rk-682
Synonym More Synonyms

 (Rac)-RK-682 Biological Activity

Description (Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively[1].
Related Catalog
Target

IC50: 8.6 μM (PTP-1B), 12.4 μM (LMW-PTP), and 0.7 μM (CDC-25B) [1]

References

[1]. Vânia M T Carneiro, et al. Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. Eur J Med Chem. 2015 Jun 5;97:42-54.

 Chemical & Physical Properties

Molecular Formula C21H36O5
Molecular Weight 368.51
Exact Mass 368.25600
PSA 83.83000
LogP 4.76660

 Synonyms

ANTIBIOTIC RK-682
3-hexadecanoyl-5-hydroxymethyl-tetronic acid
ANTIBIOTIC TAN 1364B