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29031-19-4

29031-19-4 structure
29031-19-4 structure
  • Name: 2-Amino-2-deoxy-D-glucose sulfate (1:1)
  • Chemical Name: D-Glucosamine Sulfate Salt
  • CAS Number: 29031-19-4
  • Molecular Formula: C6H13NO5.xH2O4S
  • Molecular Weight: 277.250
  • Catalog: Signaling Pathways Autophagy Autophagy
  • Create Date: 2018-02-07 08:00:00
  • Modify Date: 2024-01-03 10:55:54
  • Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

Name D-Glucosamine Sulfate Salt
Synonyms D-Glucose, 2-amino-2-deoxy-, sulfate (1:1)
D-Glucosamine sulfate
2-Amino-2-deoxy-D-glucose sulfate (1:1)
EINECS 249-379-6
MFCD00151175
Description Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity[2]. Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3]. Glucosamine sulfate significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4].
References

[1]. Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7.

[2]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9.

[3]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706.

[4]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84.

Density 1.563g/cm3
Boiling Point 449.9ºC at 760mmHg
Melting Point 176°C
Molecular Formula C6H13NO5.xH2O4S
Molecular Weight 277.250
Flash Point 225.9ºC
Exact Mass 277.046753
PSA 206.99000
Vapour Pressure 5.53E-10mmHg at 25°C
Storage condition -20?C Freezer
Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S22-S24/25
WGK Germany 3
RTECS AU7417000
HS Code 2932999099
Precursor  1

DownStream  0

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%