2-Amino-2-deoxy-D-glucose sulfate (1:1)

Modify Date: 2024-01-03 10:55:54

2-Amino-2-deoxy-D-glucose sulfate (1:1) structure	Common Name	2-Amino-2-deoxy-D-glucose sulfate (1:1)
	CAS Number	29031-19-4	Molecular Weight	277.250
	Density	1.563g/cm3	Boiling Point	449.9ºC at 760mmHg
	Molecular Formula	C₆H₁₃NO_5.xH₂O₄S	Melting Point	176°C
	MSDS	N/A	Flash Point	225.9ºC

Use of 2-Amino-2-deoxy-D-glucose sulfate (1:1)

Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

Name	D-Glucosamine Sulfate Salt
Synonym	More Synonyms

Description	Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
Target	Human Endogenous Metabolite
In Vitro	Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity[2]. Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3]. Glucosamine sulfate significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4].
References	[1]. Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7. [2]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9. [3]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706. [4]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84.

Density	1.563g/cm3
Boiling Point	449.9ºC at 760mmHg
Melting Point	176°C
Molecular Formula	C₆H₁₃NO_5.xH₂O₄S
Molecular Weight	277.250
Flash Point	225.9ºC
Exact Mass	277.046753
PSA	206.99000
Vapour Pressure	5.53E-10mmHg at 25°C
Storage condition	-20?C Freezer

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S22-S24/25
WGK Germany	3
RTECS	AU7417000
HS Code	2932999099

Precursor 1
CAS#:90-76-6 (3R,4R,5R,6R)-3...
DownStream 0

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%