Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Carmoisine (C.I. 14720)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: ACID RED B
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

3567-69-9

3567-69-9 structure

Name: Carmoisine
Chemical Name: Acidic Red B
CAS Number: 3567-69-9
Molecular Formula: C₂₀H₁₂N₂Na₂O₇S₂
Molecular Weight: 502.428
Catalog: Dyes and pigments dye Acid Dyestuff
Create Date: 2018-12-24 08:02:46
Modify Date: 2026-07-04 20:36:56
Carmoisine (Azorubine) is an azo dye that can be used as a food additive[1][2].

Name	Acidic Red B
Synonyms	11959red acetacidredb CaseinAcc.ToHammersteinForBiochemistry AcidcmoisineB Disodium 4-hydroxy-3-[(E)-(4-sulfonato-1-naphthyl)diazenyl]-1-naphthalenesulfonate Disodium 4-hydroxy-3-[(E)-(4-sulfonato-1-naphthyl)diazenyl]naphthalene-1-sulfonate 1-Naphthalenesulfonic acid, 4-hydroxy-3-(4-sulfo-1-naphthalenyl)azo-, disodium salt acidchromeblueba 1-Naphthalenesulfonic acid, 4-hydroxy-3-[(E)-2-(4-sulfo-1-naphthalenyl)diazenyl]-, sodium salt (1:2) disodium 4-hydroxy-3-[(E)-(4-sulfonato-1-naphthyl)azo]naphthalene-1-sulfonate Disodium 4-hydroxy-3-[(4-sulfo-1-naphthalenyl)azo]-1-naphthalenesulfonate foodred5 red#14 Mordant Blue 79 azorubinesspeciallypure azorubinextra CI 14720 Acid red 14 Chromotrope FB 2-(4-sulfo-1-naphthylazo)-1-naphthol-4-sulfonicacid,disodiumsalt 4-hydroxy-3-((4-sulpho-1-naphthalenyl)azo)-1-naphthalenesulphonicacid,disod 4-hydroxy-3,4’-azodi-1-naphthalenesulfonicacidisodiumsalt acidbrilliantrubine2gt disodium 4-hydroxy-3-[(E)-(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-1-sulfonate Azorubine Cmosine (chromotrop FB) azorubinexx airedalecmoisine acidchromeblueba-cf acidbrilliantrubinea2onc Acid Red 14 atulcrystaedf 4-hydroxy-3-((4-sulfo-1-naphthalenyl)azo)-1-naphthalenesulfonicacidisodiu PONTACYL RUBINE R azorubinelz amacidcmoisineb acidred2c Azo Rubine ( Dye content) Pigment organic acid red EINECS Azo Rubine S acidchromebluefbs 1-naphthalenesulfonic acid, 4-hydroxy-3-[(E)-(4-sulfo-1-naphthalenyl)azo]-, disodium salt azorubineaf 4-hydroxy-3,4’-azodi-1-naphthalenesulfonicacid,disodiumsalt AZO RUBINE EXTRA Acid red 14 4-hydroxy-3-[(4-sulfo-1-naphthalenyl)azo]-1-naphthalenesulfonic acid disudium salt 4-hydroxy-3-((4-sulfo-1-naphthalenyl)azo)-1-naphthalenesulfonicacid,disodiu Disodium 4-hydroxy-3-((4-sulphonatonaphthyl)azo)naphthalenesulphonate ChroMe becoMes priMe FB acidrubine 2-(4-sulpho-1-naphthylazo)-1-naphthol-4-sulphonicacid,disodiumsalt 4-hydroxy-3-[(4-sulfo-1-naphthalenyl)azo]-1-naphthalenesulfonicacid,disodium Carmoisine B MORDANT BLUE 79 acidchromeblue2r amacidchromebluer EINECS 222-657-4 atulacidcrystaed acidbrilliantrubine 1-Naphthalenesulfonicacid, 4-hydroxy-3-[2-(4-sulfo-1-naphthalenyl)diazenyl]-, sodiuM salt (1:2) 4-hydroxy-3,4'-azo-bis-naphthalene-1-sulfonic acid,disodium-salt azorubine(biologicalstain) Acid Cmosine S acidfastredfb carmoisin AZORUBIN acidrubineextra Naphthol bordeaux Brilliant Crimson Red MFCD00003978 E122 disodium 4-hydroxy-3-[(4-sulphonatonaphthyl)azo]naphthalenesulphonate 4-hydroxy-3-[(4-sulfo-1-naphthalenyl)azo]-1-naphthalenesulfonicacidisodiu 4-hydroxy-3,4’-azodi-1-naphthalenesulphonicacid,disodiumsalt azorubineextralc karmesin CMOISINE ciacidred azorubineforfood

Description	Carmoisine (Azorubine) is an azo dye that can be used as a food additive[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Carmoisine augments the in vitro synthesis of leukotriene B4 (LTB4) and F2-isoprostanes from blood neutrophils. Carmoisine increases the formation of F2-isoprostanes from blood neutrophils at all tested concentrations[2].
In Vivo	Carmoisine (49.3-493 mg/kg; oral administration; for 42 days; male Wistar rats) treatment increases MAPK8 expression at remarkably low and high concentrations, the expression of NFκB and GADD45α does not change[1]. Animal Model: Male Wistar rats (120-300 g)[1] Dosage: 49.3 mg/kg, 493 mg/kg Administration: Oral administration; for 42 days Result: Resulted in apoptosis according to MAPK8 expression.
References	[1]. B Raposa, et al. Food additives: Sodium benzoate, potassium sorbate, azorubine, and tartrazine modify the expression of NFκB, GADD45α, and MAPK8 genes. Physiol Int. 2016 Sep;103(3):334-343. [2]. Latasha Leo, et al. Occurrence of azo food dyes and their effects on cellular inflammatory responses. Nutrition. 2018 Feb;46:36-40.

Melting Point	>300ºC
Molecular Formula	C₂₀H₁₂N₂Na₂O₇S₂
Molecular Weight	502.428
Flash Point	>225℃
Exact Mass	501.988129
PSA	176.11000
LogP	6.08380

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK1925000

CHEMICAL NAME :: 1-Naphthalenesulfonic acid, 4-hydroxy-3,4'-azodi-, disodium salt

CAS REGISTRY NUMBER :: 3567-69-9

LAST UPDATED :: 199703

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C20-H12-N2-O7-S2.2Na

MOLECULAR WEIGHT :: 502.44

WISWESSER LINE NOTATION :: L66J BSWQ ENUN- CL66J BQ ESWQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 74 gm/kg/90D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 300 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,133,1989 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,83,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,83,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1431 No. of Facilities: 92 (estimated) No. of Industries: 3 No. of Occupations: 14 No. of Employees: 1771 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1431 No. of Facilities: 2819 (estimated) No. of Industries: 39 No. of Occupations: 49 No. of Employees: 38995 (estimated) No. of Female Employees: 8194 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	26-37/39
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	QK1925000

84-87-7

3567-69-9

Literature: DE26012 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 391 Die Anilinfarben und ihre Fabrikation, 4.Tl.,S.787 DE66838 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 3, p. 791

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