60607-35-4

60607-35-4 structure

Name: Topterone
Chemical Name: (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-17-propyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
CAS Number: 60607-35-4
Molecular Formula: C₂₂H₃₄O₂
Molecular Weight: 330.50400
Catalog: Research Areas Metabolic Disease
Create Date: 2018-09-29 20:07:31
Modify Date: 2024-01-03 11:21:47
Topterone is a topical antiandrogen.

Name	(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-17-propyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Synonyms	Topterona TOPTERONE Topterona [INN-Spanish] Topteronum [INN-Latin] Topterone (USAN/INN) Topteronum

Description	Topterone is a topical antiandrogen.
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Others >> Androgen Receptor
Target	Androgen[1]
In Vivo	Topterone, is administered parenterally or topically to rats, rabbits or hamsters to determine its endocrine profile. Systemic administration demonstrates that Topterone is both antiandrogenic and progestational. Topical application fails to elicit a systemic antiandrogenic response at 1 g/kg/day and only a minimal progestational response is seen at 32 mg/kg/day. No other endocrine activities are detected[1]. Topterone inhibits stimulation of flank organ development of castrated immature male hamsters by both testosterone and dihydrotestosterone, whereas Progesterone inhibits the stimulation by only testosterone. Topical application of Topterone, has been shown to cause a regression in the development of the flank organ[2].
References	[1]. Ferrari RA, et al. Endocrine profile of topterone, a topical antiandrogen, in three species of laboratory animals. Methods Find Exp Clin Pharmacol. 1980 Apr;2(2):65-9. [2]. Chakrabarty K, et al. Mechanism of action of 17 alpha-propyltestosterone in inhibiting hamster flank organ development. J Invest Dermatol. 1980 Jan;74(1):5-8.