4366-18-1
4366-18-1 structure
- Name: Coumetarol
- Chemical Name: 4-hydroxy-3-[1-(4-hydroxy-2-oxochromen-3-yl)-2-methoxyethyl]chromen-2-one
- CAS Number: 4366-18-1
- Molecular Formula: C21H16O7
- Molecular Weight: 380.34800
- Catalog: Research Areas Metabolic Disease
- Create Date: 2018-04-13 08:00:00
- Modify Date: 2025-08-25 10:31:46
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Coumetarol is a vitamin K antagonist.
| Name | 4-hydroxy-3-[1-(4-hydroxy-2-oxochromen-3-yl)-2-methoxyethyl]chromen-2-one |
|---|---|
| Synonyms |
Cumetarolo
3,3'-(2-methoxyethane-1,1-diyl)bis(2-hydroxy-4h-chromen-4-one) Cumetharol Cumetarol 4,4'-dihydroxy-3,3'-(2-methoxy-ethane-1,1-diyl)-bis-chromen-2-one 1,1-Bis-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-methoxy-aethan Cumetarolo [DCIT] 1,1-bis-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-methoxy-ethane Coumetarolum Coumetarol UNII-UO1VQB3SPZ |
| Description | Coumetarol is a vitamin K antagonist. |
|---|---|
| Related Catalog | |
| Target |
vitamin K[1] |
| In Vitro | Coumetarol (Dicumoxane), an oral anticoagulant, is active in both models. The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model. Treatment with the vitamin K antagonist Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments the coagulation time as measured by the Thrombotest is prolonged to the same extent[1]. |
| References |
| Molecular Formula | C21H16O7 |
|---|---|
| Molecular Weight | 380.34800 |
| Exact Mass | 380.09000 |
| PSA | 110.11000 |
| LogP | 3.08890 |
| RIDADR | UN 2811 |
|---|---|
| HS Code | 2932209090 |
|
~%
4366-18-1 |
| Literature: Veldstra et al. Recueil des Travaux Chimiques des Pays-Bas, 1953 , vol. 72, p. 358,361,364 |
| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |