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  • DC Chemicals Limited
  • China
  • Product Name: PD166866
  • Price: $550.0/100mg $950.0/250mg $1900.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

192705-79-6

192705-79-6 structure
192705-79-6 structure
  • Name: PD-166866
  • Chemical Name: 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
  • CAS Number: 192705-79-6
  • Molecular Formula: C20H24N6O3
  • Molecular Weight: 396.44300
  • Catalog: Research Areas Cancer
  • Create Date: 2016-02-22 17:44:55
  • Modify Date: 2024-01-02 21:03:03
  • PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.

Name 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
Synonyms 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea
HIF-1alpha
HMS3263L17
PD-166866
PD166866
Description PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.
Related Catalog
Target

FGFR1:52.4 nM (IC50)

In Vitro PD 166866 inhibits human full-length FGFR-1 tyrosine kinase with an IC50 value of 52.4 nM and is characterized as an ATP competitive inhibitor of the FGFR-1. PD 166866 is a potent inhibitor of FGFR autophosphorylation in NIH 3T3 cells expressing endogenous FGFR-1 and in L6 cells overexpressing the human FGFR-1 tyrosine kinase. PD 166866 also inhibits bFGF-induced tyrosine phosphorylation of the 44- and 42-kDa (ERK 1/2) mitogen-activated protein kinase isoforms in L6 cells. Daily exposure of PD 166866 to L6 cells at concentrations from 1 to 100 nM results in a concentration-related inhibition of bFGF-stimulated cell growth for 8 consecutive days with an IC50 value of 24 nM[1].
Cell Assay PD 166866 is dissolved in DMSO. PD 166866 or vehicle (0.5% DMSO, final concentration) are added every day to triplicate cultures of cells together with 25 ng/mL bFGF to stimulate FGF-driven growth. In some experiments, PD 166866 is added every day to triplicate cultures of cells together with 30 ng/mL PDGF-BB to stimulate PDGF-driven growth. Cell number is measured by Coulter counting on days 1, 3, 6 or 8 after drug exposure[1]
References

[1]. Panek RL, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998 Jul;286(1):569-77.

Density 1.277g/cm3
Molecular Formula C20H24N6O3
Molecular Weight 396.44300
Exact Mass 396.19100
PSA 128.50000
LogP 3.54580
Index of Refraction 1.643
Storage condition 2-8°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport