17355-11-2

17355-11-2 structure

Name: Tyr-Phe
Chemical Name: 2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoic acid
CAS Number: 17355-11-2
Molecular Formula: C₁₈H₂₀N₂O₄
Molecular Weight: 328.36200
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2018-12-25 18:24:59
Modify Date: 2024-01-02 15:15:02
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells[1][2][3][4].

Name	2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoic acid
Synonyms	H-Tyr-Phe-OH Tyr-Phe L-tyrosyl-L-phenylalanine tyrosylphenylalanine tyrosinylphenylalanine L-Tyrosine-L-phenylalanine

Description	H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
Target	Target: ACE (Angiotensin converting enzyme), xanthine oxidase[1]
References	[1]. Zhu Wei, et al. Biomarker containing keratin type II cytoskeleton 1b for differentiating benign thyroid nodules and thyroid cancer: China, CN114264828A[P]. 2022-04-01. [2]. Enari Hiroyuki, et al. Angiotensin converting enzyme (ACE)-inhibiting peptides, ACE inhibitors containing the peptides, their uses, and manufacture of the peptides from shark cartilage: Japan, JP2005154326A[P]. 2005-06-16. [3]. Mao Xiangchao, et al. Method for preparing cod fish peptide with xanthine oxidase inhibitory activity: China, CN113005166A[P]. 2021-06-22. [4]. Hsueh PC, et al. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Anal Chim Acta. 2020 Sep 1;1128:238-250.

Density	1.3 g/cm3
Boiling Point	642.2ºC at 760 mmHg
Molecular Formula	C₁₈H₂₀N₂O₄
Molecular Weight	328.36200
Flash Point	342.2ºC
Exact Mass	328.14200
PSA	112.65000
LogP	2.16530
Vapour Pressure	2.27E-17mmHg at 25°C
Index of Refraction	1.625

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

17355-11-2	108322-11-8
63023-95-0	38678-75-0
19391-50-5	7762-61-0
19898-34-1	119153-83-2
5147-17-1	69261-43-4
923679-79-2	1158522-08-7
941879-47-6	886888-67-1
940364-43-2	923257-91-4
134104-43-1	399043-34-6
131615-57-1	6906-52-1