75513-71-2

75513-71-2 structure

Name: Bovine adrenal medulla dodecapeptide
Chemical Name: bam-12p
CAS Number: 75513-71-2
Molecular Formula: C₆₂H₉₇N₂₁O₁₆S
Molecular Weight: 1424.63000
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2018-12-24 08:50:21
Modify Date: 2025-09-06 12:47:13
BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC50 of 101 nM and a pEC50 of 6.99. BAM-12P is a ligand for CXCR7 with an EC50 of 175 nM[1][2][3].

Name	bam-12p
Synonyms	BOVINE ADRENAL MEDULLA-12P TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-OH Peptide E(1-12) BOVINE ADRENAL MEDULLA DOCOSAPEPTIDE BOVINE ANDRENAL MEDULLA DODECAPEPTIDE YGGFMRRVGRPE BOVINE ADRENAL MEDULLA DODECAPEPTIDE

Description	BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC50 of 101 nM and a pEC50 of 6.99. BAM-12P is a ligand for CXCR7 with an EC50 of 175 nM[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Signaling Pathways >> Immunology/Inflammation >> CXCR Research Areas >> Neurological Disease
Target	human κ-opioid receptor (hKOR):101 nM (EC50) human κ-opioid receptor (hKOR):6.99 (pEC50) CXCR7:175 nM (EC50)
In Vitro	BAM-12P 在豚鼠回肠试验中显示出有效的阿片活性，IC50 为 15.5 nM[2]。
References	[1]. K Mizuno, et al. A new endogenous opioid peptide from bovine adrenal medulla: isolation and amino acid sequence of a dodecapeptide (BAM-12P). Biochem Biophys Res Commun. 1980 Aug 29;95(4):1482-8. [2]. Yuichi Ikeda, et al. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013 Dec 5;155(6):1323-36. [3]. Eyal Vardy, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86(4):936-946.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3.0