Bovine adrenal medulla dodecapeptide

Modify Date: 2024-01-02 22:12:36

Bovine adrenal medulla dodecapeptide Structure
Bovine adrenal medulla dodecapeptide structure
Common Name Bovine adrenal medulla dodecapeptide
CAS Number 75513-71-2 Molecular Weight 1424.63000
Density N/A Boiling Point N/A
Molecular Formula C62H97N21O16S Melting Point N/A
MSDS USA Flash Point N/A

 Use of Bovine adrenal medulla dodecapeptide


BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC50 of 101 nM and a pEC50 of 6.99. BAM-12P is a ligand for CXCR7 with an EC50 of 175 nM[1][2][3].

 Names

Name bam-12p
Synonym More Synonyms

 Bovine adrenal medulla dodecapeptide Biological Activity

Description BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC50 of 101 nM and a pEC50 of 6.99. BAM-12P is a ligand for CXCR7 with an EC50 of 175 nM[1][2][3].
Related Catalog
Target

human κ-opioid receptor (hKOR):101 nM (EC50)

human κ-opioid receptor (hKOR):6.99 (pEC50)

CXCR7:175 nM (EC50)

In Vitro BAM-12P 在豚鼠回肠试验中显示出有效的阿片活性,IC50 为 15.5 nM[2]。
References

[1]. K Mizuno, et al. A new endogenous opioid peptide from bovine adrenal medulla: isolation and amino acid sequence of a dodecapeptide (BAM-12P). Biochem Biophys Res Commun. 1980 Aug 29;95(4):1482-8.  

[2]. Yuichi Ikeda, et al. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013 Dec 5;155(6):1323-36.  

[3]. Eyal Vardy, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86(4):936-946.  

 Chemical & Physical Properties

Molecular Formula C62H97N21O16S
Molecular Weight 1424.63000
Exact Mass 1423.71000
PSA 643.16000
LogP 2.50620
Storage condition -20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3.0

 Articles17

More Articles
Substrate specificity of a novel serine protease from soybean [Glycine max (L.) Merrill].

J. Biochem. 119(6) , 1094-9, (1996)

The substrate specificity of a novel serine protease isolated from soybean seeds, cultivar Keburi, was investigated using various peptide-MCAs and several neuropeptides involving single and paired bas...

Opioid activity of pro-enkephalin-derived peptides in mouse vas deferens and guinea pig ileum.

Neurosci. Lett. 61(3) , 267-71, (1985)

The inhibitory activity of several pro-enkephalin A-derived opioid peptides, containing the sequence of Met-enkephalin, was evaluated in two isolated organ preparations sensitive to opioids, the guine...

A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity.

Biochem. Biophys. Res. Commun. 97 , 1283, (1980)

 Synonyms

BOVINE ADRENAL MEDULLA-12P
TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU
H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-OH
Peptide E(1-12)
BOVINE ADRENAL MEDULLA DOCOSAPEPTIDE
BOVINE ANDRENAL MEDULLA DODECAPEPTIDE
YGGFMRRVGRPE
BOVINE ADRENAL MEDULLA DODECAPEPTIDE
Top Suppliers:I want be here




Get all suppliers and price by the below link:

Bovine adrenal medulla dodecapeptide suppliers

Bovine adrenal medulla dodecapeptide price