67705-77-5
67705-77-5 structure
- Name: Bromo-PEG5-bromide
- Chemical Name: 3,6,9,12,15-Pentaoxaheptadecane-1,17-diyl Bis-bromide
- CAS Number: 67705-77-5
- Molecular Formula: C12H24Br2O5
- Molecular Weight: 408.12400
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2016-05-16 09:52:35
- Modify Date: 2024-01-10 16:00:23
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Bromo-PEG5-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 3,6,9,12,15-Pentaoxaheptadecane-1,17-diyl Bis-bromide |
|---|---|
| Synonyms | 1-[2-(2-bromoethoxy)ethoxy]-2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethane |
| Description | Bromo-PEG5-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.433g/cm3 |
|---|---|
| Boiling Point | 413.195ºC at 760 mmHg |
| Molecular Formula | C12H24Br2O5 |
| Molecular Weight | 408.12400 |
| Flash Point | 170.724ºC |
| Exact Mass | 405.99900 |
| PSA | 46.15000 |
| LogP | 1.85920 |
| Index of Refraction | 1.486 |
|
~86%
67705-77-5 |
| Literature: Biron, Eric; Otis, Francois; Meillon, Jean-Christophe; Robitaille, Martin; Lamothe, Julie; Van Hove, Patrick; Cormier, Marie-Eve; Voyer, Normand Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1279 - 1290 |
|
~%
67705-77-5 |
| Literature: Rabouin, Daniel; Perron, Valerie; N'Zemba, Blaise; C.-Gaudreault, Rene; Berube, Gervais Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 557 - 560 Title/Abstract Full Text View citing articles Show Details Berube, Gervais; Rabouin, Daniel; Perron, Valerie; N'Zemba, Blaise; Gaudreault, Rene-C.; Parent, Sophie; Asselin, Eric Steroids, 2006 , vol. 71, # 10 p. 911 - 921 |
| Precursor 2 | |
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| DownStream 0 | |