109789-40-4

109789-40-4 structure

Name: Ms-PEG6-Ms
Chemical Name: 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol,methanesulfonic acid
CAS Number: 109789-40-4
Molecular Formula: C₁₄H₃₄O₁₃S₂
Molecular Weight: 474.54200
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-11-04 10:18:28
Modify Date: 2024-01-09 22:52:30
Ms-PEG6-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol,methanesulfonic acid
Synonyms	3,6,9,12,15-Pentaoxaheptadecane-1,17-diol,dimethanesulfonate hexaethylene glycol bis(methanesulfonate) PEG6-di-OMs methanesulfonic acid 2-[2-(2-{2-[2-(2-methanesulfonyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl ester hexaethylene glycol bismesylate hexaethylene glycol dimesylate hexaethylene glycol dimethanesulfonate Ms-PEG6-Ms

Description	Ms-PEG6-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

2615-15-8

124-63-0

~99%

109789-40-4

Literature: Guenet, Aurelie; Ernest Graf; Nathalie Kyritsakas; Hosseini, Mir Wais Inorganic Chemistry, 2010 , vol. 49, # 4 p. 1872 - 1883

2615-15-8

124-63-0

~25%

109789-40-4

352439-34-0

Literature: Svedhem; Hollander; Shi; Konradsson; Liedberg; Svensson Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4494 - 4503