Shanghai Nianxing Industrial Co., Ltd
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PF 06465469Discontinued See A191400
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1407966-77-1

1407966-77-1 structure

1407966-77-1 structure

Name: PF 06465469
Chemical Name: 3-{1-[(3R)-1-Acryloyl-3-piperidinyl]-4-amino-1H-pyrazolo[3,4-d]py rimidin-3-yl}-N-(4-isopropyl-3-methylphenyl)benzamide
CAS Number: 1407966-77-1
Molecular Formula: C₃₀H₃₃N₇O₂
Molecular Weight: 523.63
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Itk
Create Date: 2016-05-19 22:44:28
Modify Date: 2026-07-01 11:48:09
PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM[1].

Name	3-{1-[(3R)-1-Acryloyl-3-piperidinyl]-4-amino-1H-pyrazolo[3,4-d]py rimidin-3-yl}-N-(4-isopropyl-3-methylphenyl)benzamide
Synonyms	(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyriMidin-3-yl]-N-(4-isopropyl-5-Methylphenyl)benzaMide 3-[4-amino-1-[(3R)-1-prop-2-enoyl-3-piperidyl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-3-methyl-phenyl)benzamide PF 06465469 Discontinued See A191400 Benzamide, 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl] (R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropyl-3-methylphenyl)benzamide PF06465469,PF 3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide (R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide pf-06465469

Description	PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Itk
Target	IC50: 2 nM (ITK)[1]
References	[1]. Mamand S, et al. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep. 2018 Sep 21;8(1):14216.

Molecular Formula	C₃₀H₃₃N₇O₂
Molecular Weight	523.63
Exact Mass	523.27000
PSA	119.03000
LogP	5.70120

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
RIDADR	NONH for all modes of transport

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