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137089-36-2

137089-36-2 structure
137089-36-2 structure
  • Name: 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
  • Chemical Name: (E)-N-[2-(2-cyclohexylethylsulfanyl)ethyl]dec-2-enamide
  • CAS Number: 137089-36-2
  • Molecular Formula: C20H37NOS
  • Molecular Weight: 339.57900
  • Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
  • Create Date: 2016-12-02 11:26:00
  • Modify Date: 2024-01-10 21:32:00
  • 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress.

Name (E)-N-[2-(2-cyclohexylethylsulfanyl)ethyl]dec-2-enamide
Synonyms 2-Decenamide,N-(2-((2-cyclohexylethyl)thio)ethyl)-,(E)
2-(E-2-decenoylamino)ethyl 2-cyclohexylethyl sulfide
2-Deces
2-(2-Decenoylamino)ethyl-2-(cyclohexylethyl)sulfide
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
Description 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress.
Related Catalog
Target

PGE2

PGI2

PLA2

In Vivo 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (compd.III-1α, 100 mg/kg, p.o.) maintains the relative content of Fr.I hexose, lipid peroxide and phospholipase A2 (PLA2) in normal level in ulcerated rats induced by water immersed restrained stress via dosing twice a day for 3 day (b.i.d. for 3 d). 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (100 mg/kg, p.o.) reduces the hexosamine content equally with the control group 4 h after the stress loading, and then markedly increases 7 h after stress loading. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (25 mg/kg, p.o.) blocks the reduction of prostaglandin E2 (PGE2) and PGI2 in early phase and accelerates the increase of PGE2 and PGI2 in the late phase of the stress. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (25 mg/kg, p.o.) also significantly accelerates the cell proliferation in fundic glands in gastric mucosa of mice[1].
References

[1]. Kohda I, et al. Further studies on the anti-ulcerogenic effects of compound, 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide. Chem Pharm Bull (Tokyo). 1991 Jul;39(7):1832-6.

Density 0.954g/cm3
Boiling Point 503.3ºC at 760 mmHg
Molecular Formula C20H37NOS
Molecular Weight 339.57900
Flash Point 258.2ºC
Exact Mass 339.26000
PSA 57.89000
LogP 6.56320
Vapour Pressure 2.93E-10mmHg at 25°C
Index of Refraction 1.498
Precursor  3

DownStream  0