1118-90-7
1118-90-7 structure
- Name: α-Aminoadipic acid
- Chemical Name: L-2-aminoadipic acid
- CAS Number: 1118-90-7
- Molecular Formula: C6H11NO4
- Molecular Weight: 161.16
- Catalog: Biochemical Amino acids and their derivatives Other amino acid derivatives
- Create Date: 2018-06-19 09:30:04
- Modify Date: 2026-07-05 18:15:01
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(S)-2-Aminohexanedioic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
| Name | L-2-aminoadipic acid |
|---|---|
| Synonyms |
L-Aad-OH
L-A- AMINOADIPIC ACIDL-2- AMINOADIPIC ACID L-2-Aminoadipic acid //BP HOMOGLUTAMIC ACID MFCD00002636 L-2-AMINOADIPIC ACID H-L-HGlu-OH L-2-Aminoadipic Acid > (S)-2-aMinohexanedioic acid α-Amino-adipic acid UNII:1K7B1OED4N L-HOMOGLUTAMIC ACID H-L-2-Aad-OH L-α-aMinoadipic acid (S)-2-Aminohexanedioic acid L-Homoglutamic acid Aad L-HomoGlutamic Acid, (S)-alpha-Aminohexandioic Acid (±)-2-Aminoadipic acid ALPHA-AMINOHEXANDIOIC ACID H-HoMoglu-OH (H-Aad-OH Hexanedioic acid,2-amino AMINOADIPIC ACID, L-2-(RG) AMINOADIPIC ACID, L-2 AAD (S)-2-Aminohexanedioic acid,L-Homoglutamic acid,Aad H-AAD-OH L-2-aminoadipicaci H-Aad-OH.HCl (2S)-2-azaniumyl-6-hydroxy-6-oxohexanoate L-2-AMINOHEXANEDIOIC ACID H-HOMOGLU-OH L-a-aMinohexanedioic acid L-A-AMINOADIPIC ACID L-2-Aminoadipic acid >= (TLC) L-2-Aminoadipic Acid Reference Material HOMOGLUTAMIC ACID, ALPHA-AMINOHEXANDIOIC ACID L-ALPHA-AMINOHEXANEDIOIC ACID L-a-AMinoadipic acid, H-HoMoglu-OH, (S)-2-AMinohexanedioic acid [S,(+)]-2-Aminoadipic acid AMINOADIPIC ACID, L-2-(P) H-L-2-Aad-OH L -2-Aminoadipic acid (2S)-2-aminohexanedioic acid L-α-Aminoadipic acid, >= H-2-AAD-OH 2-Aminohexanedioic acid a-Aminoadipate L-ALPHA-AMINOADIPIC ACI L-2-Aminoadipic acid 1-7 L-a-Amino Adipic Acid extrapure (S)-2-Aminoadipic acid L-α-Aminohexanoic Diacid (S)-2-Aminohexanedioic acid a-Aminoadipic acid H-L-HOGLU-OH (2S)-2-Aminohexanedioic acid L-2-Aminoadipic acid HEXANEDIOIC ACID, 2-AMINO-, (2S) 2-aminoadipic acid DL-2-Aminohexanedioic acid (S)-2-Amin L-ALPHA-AMINOADIPIC ACID L-aminohexanoic diacid NH2-CH[(CH2)3-COOH]-COOH L-α-Aminoadipic Acid L-a-Aminoadipic acid DL-a-aminoadipic acid Proline Impurity 15 2-AMINO-HEXANEDIOIC ACID H-AAD-OH;L-2-AMINOHEXANEDIOIC ACID |
| Description | (S)-2-Aminohexanedioic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
|---|---|
| Related Catalog | |
| In Vitro | Ki值209 μML-α-Aminoadipic Acid是一种谷氨酰胺合成酶抑制剂。谷氨酰胺合成酶是一种酶，通过催化谷氨酸和氨缩合形成谷氨酰胺，在氮代谢中发挥重要作用。体外：先前的研究发现 DL-和 L-α-氨基己二酸 (alpha-AA) 具有特异性体外胶霉毒素。在 D-或 L-α-AA 存在下进行的与 D-或 L-α-AA 和 DL-[14C]-α-AA 放射自显影图一起孵育的培养物的 HPLC 分析表明星形神经胶质细胞 L-α-AA 摄取的立体特异性。星形胶质细胞对 alpha-AA 的摄取和 alpha-AA 诱导的胶质细胞毒性都是钠依赖性的。另一项研究发现，α-氨基己二酸的 L-异构体能够竞争性抑制转运蛋白，而α-氨基己二酸的 D-异构体则无效。此外，发现 L-α 氨基己二酸是谷氨酰胺合成酶和 γ-谷氨酰半胱氨酸合成酶的竞争性抑制剂。相反，α-氨基己二酸的 D-异构体对这两种酶的抑制作用要弱得多。体内：动物研究表明，La-氨基己二酸可以剂量依赖性降低海马体中内源性细胞外犬尿酸的水平endent fashion ），尽管 La-氨基己二酸的作用似乎不如它减少从头产生的犬尿酸 。临床试验：迄今为止，尚未进行临床研究。参考文献： Huck, S., Grass, F. 和 Hrtnagl, H. 谷氨酸类似物 α-氨基己二酸在体外发挥其神经毒性作用之前被星形胶质细胞吸收。神经科学杂志 4(10), 2650-2657 (1984).麦克比恩 GJ。胶霉毒素α-氨基己二酸对大鼠纹状体中谷氨酸转运蛋白和神经胶质酶的抑制作用。Br J 药效学。1994 年 10 月；113(2):536-40. Wu HQ, Ungerstedt U, Schwarcz R. L-α-氨基己二酸作为海马体中犬尿酸生成的调节剂：自由活动大鼠的微透析研究。欧洲药理学杂志。1995 年 7 月 25 日；281(1)：55-61。 |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 364.0±32.0 °C at 760 mmHg |
| Melting Point | 203-205ºC (dec.) |
| Molecular Formula | C6H11NO4 |
| Molecular Weight | 161.16 |
| Flash Point | 173.9±25.1 °C |
| Exact Mass | 161.068802 |
| PSA | 100.62000 |
| LogP | -0.54 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.515 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2922499990 |
| Precursor 10 | |
|---|---|
| DownStream 10 | |
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |