110-94-1

110-94-1 structure

Name	glutaric acid
Synonyms	Iressa Pentanedioic acid Irressat 1,5-Pentanedioate Propane-1,3-dicarboxylic acid n-Pyrotartaric acid 1,5-Pentanedioic acid 1,3-propanedicarboxylic acid EINECS 203-817-2 hydrogen glutarate Glutaric acid ZD 1839 Gefitinib 1,3-Propanedicarboxylate MFCD00004410

Description	Glutaric acid induces oxidative stress in brain of young rats.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[1].
References	[1]. de Oliveira Marques F, et al. acid induces oxidative stress in brain of young rats. Brain Res. 2003 Feb 21;964(1):153-8.

Density	1.3±0.1 g/cm3
Boiling Point	302.9±15.0 °C at 760 mmHg
Melting Point	95-98 °C(lit.)
Molecular Formula	C₅H₈O₄
Molecular Weight	132.115
Flash Point	151.2±16.9 °C
Exact Mass	132.042252
PSA	74.60000
LogP	-1.04
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.477
Storage condition	2-8°C
Stability	Stable. Incompatible with bases, oxidizing agents, reducing agents.
Water Solubility	430 g/L (20 ºC)

REFERENCE :: BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year: 34,1196,1940 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4684 No. of Facilities: 91 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1827 (estimated) No. of Female Employees: 432 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	MA3740000
HS Code	2932999099

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%