66966-38-9

66966-38-9 structure

Name: Ethyl pyruvate-d3
Chemical Name: ethyl pyruvate (3,3,3-d3)
CAS Number: 66966-38-9
Molecular Formula: C₅H₅D₃O₃
Molecular Weight: 119.13400
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-08-31 10:11:31
Modify Date: 2024-01-31 12:02:14
Ethyl pyruvate-d3 is the deuterium labeled Ethyl pyruvate[1]. Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate is an anti-inflammatory agent[2].

Name	ethyl pyruvate (3,3,3-d3)
Synonyms	Ethyl-pyruvat-d3 Ethyl-pyridyl-4-ketimin Ethyl-pyrid-4-yl-ketimin PYRIDINE,4-PROPIONIMIDOYL 3,3,3-trideuterio-2-oxo-propionic acid ethyl ester 1-pyridin-4-yl-propylideneamine

Description	Ethyl pyruvate-d3 is the deuterium labeled Ethyl pyruvate[1]. Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate is an anti-inflammatory agent[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Fink MP. Ethyl pyruvate: a novel anti-inflammatory agent. J Intern Med. 2007 Apr;261(4):349-62. [3]. Olcum M, Tufekci KU, Durur DY, et al. Ethyl Pyruvate Attenuates Microglial NLRP3 Inflammasome Activation via Inhibition of HMGB1/NF-κB/miR-223 Signaling. Antioxidants (Basel). 202110(5):745.