852536-39-1
852536-39-1 structure
- Name: ME-143
- Chemical Name: 3,4-Bis(4-hydroxyphenyl)-7-chromanol
- CAS Number: 852536-39-1
- Molecular Formula: C21H18O4
- Molecular Weight: 334.36500
- Catalog: Research Areas Cancer
- Create Date: 2016-07-22 08:08:57
- Modify Date: 2024-01-10 14:21:04
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ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo[1].
| Name | 3,4-Bis(4-hydroxyphenyl)-7-chromanol |
|---|---|
| Synonyms |
3-(4-hydroxy-phenyl)-2-phenyl-thiazolidin-4-one
3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)chroman-7-ol 4-Thiazolidinone,3-(4-hydroxyphenyl)-2-phenyl |
| Description | ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo[1]. |
|---|---|
| Related Catalog | |
| Target |
NADH oxidase[1] |
| In Vitro | ME-143 (0-100 μM; 48 hours) reduces proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and is more potent than Genistein[1]. Cell Proliferation Assay[1] Cell Line: RKO cell; DLD1 cell Concentration: 0-100 μM Incubation Time: 48 hours Result: Reduced proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and was more potent than Genistein. |
| In Vivo | NADH氧化酶抑制剂 |
| References |
| Molecular Formula | C21H18O4 |
|---|---|
| Molecular Weight | 334.36500 |
| Exact Mass | 334.12100 |
| PSA | 69.92000 |
| LogP | 4.11150 |
|
~%
852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; Location in patent: Page/Page column 36; 37 ; |
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852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; |
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852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; |
|
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852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; |
|
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852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; |
|
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852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; |
| Precursor 6 | |
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| DownStream 0 | |