ME-143
Modify Date: 2024-01-10 14:21:04
ME-143 structure
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Common Name | ME-143 | ||
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| CAS Number | 852536-39-1 | Molecular Weight | 334.36500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H18O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ME-143ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo[1]. |
| Name | 3,4-Bis(4-hydroxyphenyl)-7-chromanol |
|---|---|
| Synonym | More Synonyms |
| Description | ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo[1]. |
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| Related Catalog | |
| Target |
NADH oxidase[1] |
| In Vitro | ME-143 (0-100 μM; 48 hours) reduces proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and is more potent than Genistein[1]. Cell Proliferation Assay[1] Cell Line: RKO cell; DLD1 cell Concentration: 0-100 μM Incubation Time: 48 hours Result: Reduced proliferation of DLD1 cell line by approximately 40% at a concentration of 3.125 μM, and was more potent than Genistein. |
| In Vivo | NADH氧化酶抑制剂 |
| References |
| Molecular Formula | C21H18O4 |
|---|---|
| Molecular Weight | 334.36500 |
| Exact Mass | 334.12100 |
| PSA | 69.92000 |
| LogP | 4.11150 |
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ME-143 CAS#:852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; Location in patent: Page/Page column 36; 37 ; |
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ME-143 CAS#:852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; |
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ME-143 CAS#:852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; |
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ME-143 CAS#:852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; |
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ME-143 CAS#:852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; |
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ME-143 CAS#:852536-39-1 |
| Literature: MARSHALL EDWARDS, INC.; JEOFFREYS, George; JOHNSON, Alison; MORENO, Ofir Patent: WO2012/61409 A1, 2012 ; |
| 3-(4-hydroxy-phenyl)-2-phenyl-thiazolidin-4-one |
| 3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)chroman-7-ol |
| 4-Thiazolidinone,3-(4-hydroxyphenyl)-2-phenyl |