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182167-02-8

182167-02-8 structure
182167-02-8 structure
  • Name: Acolbifene
  • Chemical Name: (2S)-3-(4-Hydroxyphenyl)-4-methyl-2-{4-[2-(1-piperidinyl)ethoxy]p henyl}-2H-chromen-7-ol hydrochloride (1:1)
  • CAS Number: 182167-02-8
  • Molecular Formula: C29H31NO4
  • Molecular Weight: 457.56
  • Catalog: Research Areas Cancer
  • Create Date: 2016-07-14 10:48:11
  • Modify Date: 2024-01-09 11:59:12
  • Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 22±3 nM.

Name (2S)-3-(4-Hydroxyphenyl)-4-methyl-2-{4-[2-(1-piperidinyl)ethoxy]p henyl}-2H-chromen-7-ol hydrochloride (1:1)
Synonyms (S)-3-(4-carboxybenzyl)willardiine
(aS)-a-Amino-3-((4-carboxyphenyl)methyl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoicacid
(S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol
UBP 282
Description Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 22±3 nM.
Related Catalog
References

[1]. Wang T, et al. Recent advances in selective estrogen receptor modulators for breast cancer. Mini Rev Med Chem. 2009 Sep;9(10):1191-201.

Boiling Point 651.5ºC at 760mmHg
Molecular Formula C29H31NO4
Molecular Weight 457.56
Flash Point 347.8ºC
PSA 62.16000
LogP 6.76680

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182167-02-8 structure

182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

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182167-02-8 structure

182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

~%

182167-02-8 structure

182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

~%

182167-02-8 structure

182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

~%

182167-02-8 structure

182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

~%

182167-02-8 structure

182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

~%

182167-02-8 structure

182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122