925705-73-3

925705-73-3 structure

Name: TG100713
Chemical Name: 3-(2,4-diaminopteridin-6-yl)phenol
CAS Number: 925705-73-3
Molecular Formula: C₁₂H₁₀N₆O
Molecular Weight: 254.247
Catalog: Biochemical Inhibitor PI3K/Akt/mTOR inhibitor (PI3K/Akt/mTOR) PI3K inhibitor
Create Date: 2017-07-16 13:21:24
Modify Date: 2024-01-07 11:17:59
TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively[1].

Name	3-(2,4-diaminopteridin-6-yl)phenol
Synonyms	cc-655 Phenol, 3-(2,4-diamino-6-pteridinyl)- 3-(2,4-Diamino-6-pteridinyl)phenol Phenol,3-(2,4-diamino-6-pteridinyl)

Description	TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kδ:24 nM (IC50) PI3Kγ:50 nM (IC50) PI3Kα:165 nM (IC50) PI3Kβ:215 nM (IC50)
In Vitro	TG100713 (10 μM; 48 or 72 h) strongly inhibits endothelial cell (EC) proliferation[1].
References	[1]. Doukas J, et, al. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71.