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638156-11-3

638156-11-3 structure
638156-11-3 structure
  • Name: CID-2011756
  • Chemical Name: 5-(3-chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide
  • CAS Number: 638156-11-3
  • Molecular Formula: C22H21ClN2O3
  • Molecular Weight: 396.867
  • Catalog: Signaling Pathways Apoptosis PKD
  • Create Date: 2018-12-20 17:40:33
  • Modify Date: 2024-01-19 10:04:52
  • CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.
Name 5-(3-chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide
Synonyms QCR-12
5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furamide
HMS2426M13
2-Furancarboxamide, 5-(3-chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-
cc-693
CID-2011756
CID 2011756
Description CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.
Related Catalog
Target

Cellular PKD2:0.6 μM (IC50)

Cellular PKD3:0.7 μM (IC50)

PKD1:3.2 μM (IC50)

In Vitro CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC50 of 3.2 µM. CID 2011756 decreases the phosphorylation of endogenous PKD1 Ser916 in LNCaP cancer cells with an EC50 of 10±0.7 µM. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC50s of 0.6±0.1 µM and 0.7±0.2 µM for PKD2 and PKD3, respectively[1].
References

[1]. Sharlow ER, et al. Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS One. 2011;6(10):e25134.
Density 1.3±0.1 g/cm3
Boiling Point 491.0±45.0 °C at 760 mmHg
Molecular Formula C22H21ClN2O3
Molecular Weight 396.867
Flash Point 250.8±28.7 °C
Exact Mass 396.124084
PSA 58.20000
LogP 3.69
Appearance white solid
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.633
Storage condition -20℃
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P305 + P351 + P338
RIDADR NONH for all modes of transport

Chemsrc provides CAS#:638156-11-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 638156-11-3 | Chemsrc address: https://m.chemsrc.com/en/baike/454844.html

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