DC Chemicals Limited
China
Product Name: PHA690509
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

492445-28-0

492445-28-0 structure

Name: PHA690509
Chemical Name: (2S)-2-(4-Acetamidophenyl)-N-(5-isopropyl-1,3-thiazol-2-yl)propan amide
CAS Number: 492445-28-0
Molecular Formula: C₁₇H₂₁N₃O₂S
Molecular Weight: 331.432
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2017-11-04 05:58:48
Modify Date: 2024-09-14 19:31:07
PHA-690509 is an anti-ZikV compound that inhibits ZikV replication. PHA-690509 is also a CDK inhibitor, and inhibits caspase-3 activity[1][2].

Name	(2S)-2-(4-Acetamidophenyl)-N-(5-isopropyl-1,3-thiazol-2-yl)propan amide
Synonyms	(2S)-2-(4-Acetamidophenyl)-N-(5-isopropyl-1,3-thiazol-2-yl)propanamide (2S)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno-[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide NOP-1A (2S)-2-[4-(acetylamino)phenyl]-N-(5-isopropyl-1,3-thiazol-2-yl)propanamide Benzeneacetamide, 4-(acetylamino)-α-methyl-N-[5-(1-methylethyl)-2-thiazolyl]-, (αS)- (2S)-2-[(3,6-diethylpyrazin-2-yl)amino]butan-1-ol

Description	PHA-690509 is an anti-ZikV compound that inhibits ZikV replication. PHA-690509 is also a CDK inhibitor, and inhibits caspase-3 activity[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
References	[1]. Devillers J. Repurposing drugs for use against Zika virus infection. SAR QSAR Environ Res. 2018 Feb;29(2):103-115. [2]. Alam A, et al. Recent trends in ZikV research: A step away from cure. Biomed Pharmacother. 2017 Jul;91:1152-1159.

Density	1.2±0.1 g/cm3
Molecular Formula	C₁₇H₂₁N₃O₂S
Molecular Weight	331.432
Exact Mass	331.135437
PSA	106.31000
LogP	3.09
Index of Refraction	1.629

492445-63-3

492445-28-0

Literature: Pevarello, Paolo; Amici, Raffaella; Villa, Manuela; Solom, Barbara; Vulpetti, Anna; Varasi, Mario; Brasca, Maria Gabriella; Traquandi, Gabriella; Nesi, Marcella Patent: US2004/235919 A1, 2004 ; US 20040235919 A1

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