PHA690509

Modify Date: 2024-09-14 19:31:07

PHA690509 Structure
PHA690509 structure
Common Name PHA690509
CAS Number 492445-28-0 Molecular Weight 331.432
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C17H21N3O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PHA690509


PHA-690509 is an anti-ZikV compound that inhibits ZikV replication. PHA-690509 is also a CDK inhibitor, and inhibits caspase-3 activity[1][2].

 Names

Name (2S)-2-(4-Acetamidophenyl)-N-(5-isopropyl-1,3-thiazol-2-yl)propan amide
Synonym More Synonyms

 PHA690509 Biological Activity

Description PHA-690509 is an anti-ZikV compound that inhibits ZikV replication. PHA-690509 is also a CDK inhibitor, and inhibits caspase-3 activity[1][2].
Related Catalog
References

[1]. Devillers J. Repurposing drugs for use against Zika virus infection. SAR QSAR Environ Res. 2018 Feb;29(2):103-115.  

[2]. Alam A, et al. Recent trends in ZikV research: A step away from cure. Biomed Pharmacother. 2017 Jul;91:1152-1159.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Molecular Formula C17H21N3O2S
Molecular Weight 331.432
Exact Mass 331.135437
PSA 106.31000
LogP 3.09
Index of Refraction 1.629

 Synthetic Route

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PHA690509 Structure

PHA690509

CAS#:492445-28-0

Literature: Pevarello, Paolo; Amici, Raffaella; Villa, Manuela; Solom, Barbara; Vulpetti, Anna; Varasi, Mario; Brasca, Maria Gabriella; Traquandi, Gabriella; Nesi, Marcella Patent: US2004/235919 A1, 2004 ; US 20040235919 A1

 Synonyms

(2S)-2-(4-Acetamidophenyl)-N-(5-isopropyl-1,3-thiazol-2-yl)propanamide
(2S)-2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno-[2,3-c]pyran-7,4'-piperidine]-1'-yl)-N-methylpropanamide
NOP-1A
(2S)-2-[4-(acetylamino)phenyl]-N-(5-isopropyl-1,3-thiazol-2-yl)propanamide
Benzeneacetamide, 4-(acetylamino)-α-methyl-N-[5-(1-methylethyl)-2-thiazolyl]-, (αS)-
(2S)-2-[(3,6-diethylpyrazin-2-yl)amino]butan-1-ol
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