127785-64-2

127785-64-2 structure

Name: Basifungin
Chemical Name: aureobasidin A
CAS Number: 127785-64-2
Molecular Formula: C₆₀H₉₂N₈O₁₁
Molecular Weight: 1101.42000
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-08-26 10:26:11
Modify Date: 2024-01-09 18:18:37
Aureobasidin A (Basifungin), a cyclic depsipetide, is an antifungal antibiotic. Aureobasidin A (Basifungin) A is an inhibitor of the inositolphosphorylceramide synthase AUR1[1][2].

Name	aureobasidin A
Synonyms	aurantoside B

Description	Aureobasidin A (Basifungin), a cyclic depsipetide, is an antifungal antibiotic. Aureobasidin A (Basifungin) A is an inhibitor of the inositolphosphorylceramide synthase AUR1[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology
In Vitro	Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides[2].
References	[1]. K Ikai, et al. Structure of aureobasidin A. J Antibiot (Tokyo). 1991 Sep;44(9):925-33. [2]. Vanessa Cerantola, et al. Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Mol Microbiol. 2009 Mar;71(6):1523-37. [3]. K Kino, et al. Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins. FEBS Lett. 1996 Dec 9;399(1-2):29-32.