77011-63-3
77011-63-3 structure
- Name: BECLOMETASONE DIPROPIONATE MONOHYDRATE
- Chemical Name: [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate,hydrate
- CAS Number: 77011-63-3
- Molecular Formula: C34H51ClO12
- Molecular Weight: 687.21500
- Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
- Create Date: 2016-08-31 18:15:38
- Modify Date: 2025-09-08 18:55:50
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Beclometasone dipropionate monohydrate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma [1][2].
| Name | [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate,hydrate |
|---|---|
| Synonyms |
4H7L9AI22I
beclomethasone dipropionate monohydrate UNII-4H7L9AI22I |
| Description | Beclometasone dipropionate monohydrate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma [1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Beclometasone dipropionate monohydrate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells[2]. Western Blot Analysis[2] Cell Line: 16HBE cells Concentration: 1, 10 and 100 nM Incubation Time: 20 min Result: Reduced the levels of iNOS, ROS and NT generated by rhIL-17A. |
| In Vivo | Beclometasone dipropionate monohydrate (150 µg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number[1]. Animal Model: Male BALB/c mice with asthma[1] Dosage: 150 µg/kg Administration: Nebulization Result: Decreased total cell number and relative eosinophil number in BALF. |
| References |
| Molecular Formula | C34H51ClO12 |
|---|---|
| Molecular Weight | 687.21500 |
| Exact Mass | 686.30700 |
| PSA | 190.80000 |
| LogP | 4.98450 |