Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: BECLOMETASONE DIPROPIONATE MONOHYDRATE
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Purity: 98.0%
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77011-63-3

77011-63-3 structure

Name: BECLOMETASONE DIPROPIONATE MONOHYDRATE
Chemical Name: [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate,hydrate
CAS Number: 77011-63-3
Molecular Formula: C₃₄H₅₁ClO₁₂
Molecular Weight: 687.21500
Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
Create Date: 2016-08-31 18:15:38
Modify Date: 2024-01-04 17:10:54
Beclometasone dipropionate monohydrate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma [1][2].

Name	[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate,hydrate
Synonyms	4H7L9AI22I beclomethasone dipropionate monohydrate UNII-4H7L9AI22I

Description	Beclometasone dipropionate monohydrate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma [1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	Beclometasone dipropionate monohydrate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells[2]. Western Blot Analysis[2] Cell Line: 16HBE cells Concentration: 1, 10 and 100 nM Incubation Time: 20 min Result: Reduced the levels of iNOS, ROS and NT generated by rhIL-17A.
In Vivo	Beclometasone dipropionate monohydrate (150 µg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number[1]. Animal Model: Male BALB/c mice with asthma[1] Dosage: 150 µg/kg Administration: Nebulization Result: Decreased total cell number and relative eosinophil number in BALF.
References	[1]. Hrvacić B, et, al. Applicability of an ultrasonic nebulization system for the airways delivery of beclomethasone dipropionate in a murine model of asthma. Pharm Res. 2006 Aug;23(8):1765-75. [2]. Montalbano AM, et, al. Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells. Eur J Pharmacol. 2013 Oct 15;718(1-3):418-27.

Molecular Formula	C₃₄H₅₁ClO₁₂
Molecular Weight	687.21500
Exact Mass	686.30700
PSA	190.80000
LogP	4.98450

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