Name | 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol |
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Synonyms |
3-[6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]- K02288 |
Description | K02288 is a potent inhibitor of ALK, and inhibits ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; K02288 is less potent against ALK4/5, with IC50s of 302 nM and 321 nM. |
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Related Catalog | |
Target |
IC50:1.8 nM (ALK1), 1.1 nM (ALK2), 34.4 nM (ALK3), 6.3 nM (ALK6), 302 nM (ALK4), 321 nM (ALK5)[1] |
In Vitro | K02288 reduces a robust phosphorylation of Smad1/5/8 induced by BMP4 stimulation, with an apparent IC50 of 100 nM. K02288 causes near complete inhibition of Smad2 phosphorylation at 0.5 µM[1]. K02288 binds to ALK1 in an ATP-mimetic fashion with two hydrogen bonds to the kinase hinge. K02288 also inhibits BMP9-ALK1 signalling, and induces a hypersprouting phenotype in HUVECs[2]. |
In Vivo | K02288 (1 µM) induces dysfunctional angiogenesis in a chick embryo CAM model[2]. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 522.2±50.0 °C at 760 mmHg |
Molecular Formula | C20H20N2O4 |
Molecular Weight | 352.384 |
Flash Point | 269.6±30.1 °C |
Exact Mass | 352.142303 |
PSA | 86.83000 |
LogP | 3.13 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.614 |
Symbol |
GHS05, GHS06 |
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Signal Word | Danger |
Hazard Statements | H301-H318 |
Precautionary Statements | P280-P301 + P310 + P330-P305 + P351 + P338 + P310 |
RIDADR | UN 2811 6.1 / PGIII |