10179-57-4
10179-57-4 structure
- Name: MLS-573151
- Chemical Name: 4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
- CAS Number: 10179-57-4
- Molecular Formula: C21H19N3O2S
- Molecular Weight: 377.460
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2017-07-08 12:11:03
- Modify Date: 2024-02-03 16:08:45
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MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42[1][2].
| Name | 4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide |
|---|---|
| Synonyms |
4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
1-<4-Pyrrolidinomethyl-phenyl>-2-phenyl-6-methoxy-3,4-dihydronaphthalin-hydrochlorid Benzenesulfonamide, 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)- MLS-573151 |
| Description | MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | The fluorescence intensities of phagocytosed beads or bacteria in hemocytes, taken as a measure of phagocytosis efficiency, were markedly reduced in granulocytes treated with MLS-573151 (50 μM; for 15 min) compared to that in the control group. MLS-573151 could effectively inhibit the phagocytic ability of granulocytes[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 596.3±60.0 °C at 760 mmHg |
| Molecular Formula | C21H19N3O2S |
| Molecular Weight | 377.460 |
| Flash Point | 314.5±32.9 °C |
| Exact Mass | 377.119812 |
| PSA | 84.14000 |
| LogP | 1.90 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.669 |
