1013750-77-0

1013750-77-0 structure

Name: ML-030
Chemical Name: 3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazol o[3,4-b][1,3,4]thiadiazine
CAS Number: 1013750-77-0
Molecular Formula: C₂₀H₂₀N₄O₄S
Molecular Weight: 412.462
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2016-10-02 20:05:52
Modify Date: 2025-08-27 18:02:00
ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.

Name	3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazol o[3,4-b][1,3,4]thiadiazine
Synonyms	3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)- ML-030

Description	ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	IC50: 6.7 nM (PDE4A), 12.9 nM (PDE4A1), 48.2 nM (PDE4B1), 37.2 (PDE4B2) nM, 452 (PDE4C1) nM, 49.2 (PDE4D2) nM[1]
In Vitro	ML-030 is potent in cell-based assay with an EC50 value of 18.7 nM[1].
References	[1]. Skoumbourdis AP, et al. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3686-92.