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1416133-89-5

1416133-89-5 structure
1416133-89-5 structure
  • Name: JW 642
  • Chemical Name: 1,1,1,3,3,3-Hexafluoro-2-propanyl 4-(3-phenoxybenzyl)-1-piperazin ecarboxylate
  • CAS Number: 1416133-89-5
  • Molecular Formula: C21H20F6N2O3
  • Molecular Weight: 462.385
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease MAGL
  • Create Date: 2016-09-11 01:12:09
  • Modify Date: 2024-01-10 20:08:13
  • JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.IC50 value: 7.6/14/3.7 nM(mouse/rat/human MAGL) [1]Target: MAGL inhibitorJW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).

Name 1,1,1,3,3,3-Hexafluoro-2-propanyl 4-(3-phenoxybenzyl)-1-piperazin ecarboxylate
Synonyms 1,1,1,3,3,3-Hexafluoro-2-propanyl 4-(3-phenoxybenzyl)-1-piperazinecarboxylate
1,1,1,3,3,3-hexafluoroisopropyl cyanoacetate
1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
JW 642
JW-642
Description JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.IC50 value: 7.6/14/3.7 nM(mouse/rat/human MAGL) [1]Target: MAGL inhibitorJW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).
Related Catalog
References

[1]. Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-88.

Density 1.4±0.1 g/cm3
Boiling Point 432.9±45.0 °C at 760 mmHg
Molecular Formula C21H20F6N2O3
Molecular Weight 462.385
Flash Point 215.6±28.7 °C
Exact Mass 462.137817
PSA 42.01000
LogP 6.43
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.511
Storage condition 2-8℃