109232-76-0

109232-76-0 structure

Name: camellianin B
Chemical Name: 5-[(2S,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
CAS Number: 109232-76-0
Molecular Formula: C₂₇H₃₀O₁₄
Molecular Weight: 578.51900
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2017-10-16 04:45:58
Modify Date: 2024-01-10 10:51:14
Camellianin B, a flavonoid compound, is a Camellianin A metabolite. Camellianin B has antioxidant and angiotensin converting enzyme (ACE) inhibitory activities[1][2].

Name	5-[(2S,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
Synonyms	Camellianin B

Description	Camellianin B, a flavonoid compound, is a Camellianin A metabolite. Camellianin B has antioxidant and angiotensin converting enzyme (ACE) inhibitory activities[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Metabolic Disease
In Vitro	At 500 μg/mL, the ACE inhibitory activities of Camellianin B is 40.68%. Camellianin B has DPPH radical scavenging activity with IC50 value of 1.8 mg/mL[2].
In Vivo	Camellianin B has a wide tissue distribution with brain penetration[1].
References	[1]. Yunliang Zheng, et al. Pharmacokinetics and tissue distribution study of camellianin A and its major metabolite in rats by liquid chromatography with tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 1;997:200-9. [2]. Benguo Liu, et al. Antioxidant and angiotensin converting enzyme (ACE) inhibitory activities of ethanol extract and pure flavonoids from Adinandra nitida leaves. Pharm Biol. 2010 Dec;48(12):1432-8.