1092484-56-4

1092484-56-4 structure
1092484-56-4 structure
  • Name: Fenofibrate-d6
  • Chemical Name: propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-3,3,3-trideuterio-2-(trideuteriomethyl)propanoate
  • CAS Number: 1092484-56-4
  • Molecular Formula: C20H15ClD6O4
  • Molecular Weight: 366.868
  • Catalog: Signaling Pathways Autophagy Autophagy
  • Create Date: 2018-08-22 15:33:13
  • Modify Date: 2024-01-14 07:12:33
  • Fenofibrate-d6 is the deuterium labeled Fenofibrate. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

Name propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-3,3,3-trideuterio-2-(trideuteriomethyl)propanoate
Synonyms Lipirex-d6
Nolipax-d6
Isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-(H)methyl(H)propanoate
Lipofene-d6
Lipsin-d6
Lipantil-d6
Lipanthyl-d6
Propanoic-3,3,3-d acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-(methyl-d)-, 1-methylethyl ester
Fenofibrate-d6
Liposit-d6
MeltDose-d6
Lipoclar-d6
Description Fenofibrate-d6 is the deuterium labeled Fenofibrate. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Schelleman H, et al. Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. Br J Clin Pharmacol. 2014 Sep;78(3):639-48.

[3]. Gong Y, et al. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Sep 30. pii: S2352-3964(16)30448-0.

Density 1.2±0.1 g/cm3
Boiling Point 469.8±35.0 °C at 760 mmHg
Molecular Formula C20H15ClD6O4
Molecular Weight 366.868
Flash Point 165.4±24.9 °C
Exact Mass 366.150482
PSA 52.60000
LogP 4.80
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.547