1201438-56-3
- Name: Duvelisib (IPI-145, INK1197)
- Chemical Name: 8-chloro-2-phenyl-3-[(1S)-1-(7H-purin-6-ylamino)ethyl]isoquinolin-1-one
- CAS Number: 1201438-56-3
- Molecular Formula: C22H17ClN6O
- Molecular Weight: 416.863
- Catalog: Biochemical Inhibitor PI3K/Akt/mTOR inhibitor (PI3K/Akt/mTOR) PI3K inhibitor
- Create Date: 2016-09-01 20:57:02
- Modify Date: 2025-08-20 08:10:36
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Duvelisib is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively.
| Name | 8-chloro-2-phenyl-3-[(1S)-1-(7H-purin-6-ylamino)ethyl]isoquinolin-1-one |
|---|---|
| Synonyms |
8-Chloro-2-phenyl-3-[(1S)-1-(3H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone
IPI-145 1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]- UNII-610V23S0JI INK1197 INK-1197 duvelisib |
| Description | Duvelisib is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively. |
|---|---|
| Related Catalog | |
| Target |
p110δ:2.5 nM (IC50) p110γ:27.4 nM (IC50) p110β:85 nM (IC50) p110α:1602 nM (IC50) |
| In Vitro | PI3Kδ and PI3Kγ inhibition with IPI-145 has anti-proliferative activity in primary AML cells by inhibiting the activity of AKT and MAPK. Pre-treatment of AML cells with IPI-145 inhibits both adhesion and migration of AML blasts to bone marrow stromal cells[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H17ClN6O |
| Molecular Weight | 416.863 |
| Exact Mass | 416.115234 |
| PSA | 88.49000 |
| LogP | 4.60 |
| Index of Refraction | 1.757 |
| Storage condition | -20°C |
|
~94%
1201438-56-3 |
| Literature: Ren, Pingda; Martin, Michael; Isbester, Paul; Lane, Benjamin S.; Kropp, Jason Patent: US2012/184568 A1, 2012 ; Location in patent: Page/Page column 83-84 ; |
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1201438-56-3 |
| Literature: WO2011/146882 A1, ; WO 2011/146882 A1 |
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1201438-56-3 |
| Literature: WO2011/146882 A1, ; WO 2011/146882 A1 |
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1201438-56-3 |
| Literature: WO2011/146882 A1, ; WO 2011/146882 A1 |
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1201438-56-3 |
| Literature: US2012/184568 A1, ; |
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1201438-56-3 |
| Literature: US2012/184568 A1, ; |
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1201438-56-3 |
| Literature: WO2011/146882 A1, ; WO 2011/146882 A1 |
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~%
1201438-56-3 |
| Literature: US2012/184568 A1, ; |
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1201438-56-3 |
| Literature: US2012/184568 A1, ; |
| Precursor 6 | |
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| DownStream 0 | |