172705-89-4

172705-89-4 structure

Name: hx 600
Chemical Name: 4-(5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid
CAS Number: 172705-89-4
Molecular Formula: C₂₉H₃₀N₂O₂
Molecular Weight: 438.56
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2016-06-24 10:28:45
Modify Date: 2024-01-22 14:54:31
HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity[1].

Name	4-(5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid
Synonyms	hx 600 4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)-Benzoic acid

Description	HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RXR α:1.9 μM (Ki) RXR β:0.64 μM (Ki) RXR γ:1 μM (Ki)
References	[1]. Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11(2):164-71. [2]. Hiroki Umemiya, et al. Action Mechanism of Retinoid-Synergistic Dibenzodiazepines. Biochem Biophys Res Commun. 1997 Apr 7;233(1):121-5.