hx 600

Modify Date: 2024-01-22 14:54:31

hx 600 Structure
hx 600 structure
Common Name hx 600
CAS Number 172705-89-4 Molecular Weight 438.56
Density 1.176g/cm3 Boiling Point 589.595°C at 760 mmHg
Molecular Formula C29H30N2O2 Melting Point N/A
MSDS N/A Flash Point 310.376°C

 Use of hx 600


HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity[1].

 Names

Name 4-(5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid
Synonym More Synonyms

 hx 600 Biological Activity

Description HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity[1].
Related Catalog
Target

RXR α:1.9 μM (Ki)

RXR β:0.64 μM (Ki)

RXR γ:1 μM (Ki)

References

[1]. Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11(2):164-71.  

[2]. Hiroki Umemiya, et al. Action Mechanism of Retinoid-Synergistic Dibenzodiazepines. Biochem Biophys Res Commun. 1997 Apr 7;233(1):121-5.  

 Chemical & Physical Properties

Density 1.176g/cm3
Boiling Point 589.595°C at 760 mmHg
Molecular Formula C29H30N2O2
Molecular Weight 438.56
Flash Point 310.376°C
Exact Mass 438.23100
PSA 52.90000
LogP 6.48480

 Synonyms

hx 600
4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)-Benzoic acid
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Price: ¥1800/1 mg

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