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  • DC Chemicals Limited
  • China
  • Product Name: Bms-193885
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

186185-03-5

186185-03-5 structure
186185-03-5 structure
  • Name: BMS 193885
  • Chemical Name: dimethyl 4-[3-[3-[4-(3-methoxyphenyl)piperidin-1-yl]propylcarbamoylamino]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • CAS Number: 186185-03-5
  • Molecular Formula: C33H42N4O6
  • Molecular Weight: 590.71000
  • Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
  • Create Date: 2016-10-09 05:54:02
  • Modify Date: 2024-01-06 06:21:22
  • BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively [1] [2].

Name dimethyl 4-[3-[3-[4-(3-methoxyphenyl)piperidin-1-yl]propylcarbamoylamino]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms MFCD16878998
Description BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively [1] [2].
Related Catalog
Target

Ki: 3.3 nM (Neuropeptide Y1 receptor)[1] IC50: 5.9 nM (hY1)[1]

References

[1]. Antal-Zimanyi I, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32.

[2]. Poindexter GS, et al. Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12(3):379-82.

Molecular Formula C33H42N4O6
Molecular Weight 590.71000
Exact Mass 590.31000
PSA 121.72000
LogP 5.21130
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport